Pharmacokinetics of pefloxacin following single dose intravenous administration (10mg/kg) was investigated in healthy Ongole calves. The drug was assayed in serum by microbiological assay. Following intravenous administration, serum concentration-time curve was best fitted to two compartment open model. Therapeutic concentration of the drug was maintained in serum up to 10 hours. The drug was widely (Vd (area) 0.856±0.007 L/kg) and equally distributed between central and peripheral compartments as evinced by the fraction of the drug in the central compartment (0.500±0.003). Ongole calves exhibited an elimination half-life of 1.732±0.12 h and high values of area under curve (61.682±0.515 µg.h2/ml). The mean residence time was 2.112±0.012 h with total clearance of 0.342±0.001 L/kg/h. The concentration of the drug to exhibit the pharmacological effect was detectable up to 10 h.
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